It was reported that increased serum IgE levels and infiltration of mast cells in AD-like skin lesions were prominent features in AD-like mouse models induced by haptens, such as OX, 2,4-dinitrofluorobenzene (DNFB) and 2,4,6-trinitrochlorobenzene (TNCB) [28,29,30]. This evidence concerns the gene IGHE and Alzheimer disease.