The main findings in this study were as follows: (1) we reported the spectrum of genetic variations in 29 BrS-susceptibility genes in a suspected BrS cohort from China; (2) we identified one novel mutation in TTN, one novel mutation in KCNH2, and two novel mutations in SCN5A; and (3) we found that the electrocardiographic axes should also be considered when predicting the risk of arrhythmias in BrS patients. Here, TTN is linked to Arrhythmia.