More studies are required to unravel the role of distinct CAV1 pathogenic variants in different types of congenital lipodystrophies, such as CGL3, FPLD7, and the neonatal onset of generalized lipodystrophy (Cao et al., 2008; Schrauwen et al., 2015; Garg et al., 2015). This evidence concerns the gene CAV1 and lipodystrophy.