At metabolic and physiological levels, CGL subjects present dyslipidemia, hyperinsulinemia, IR, DM, low levels of leptin and adiponectin, decreased levels of high-density lipoprotein cholesterol (HDL-c), hepatosplenomegaly, and hypertrophic cardiomyopathy (Faria et al., 2009; Lima et al., 2016; de Azevedo Medeiros et al., 2017; Ponte et al., 2018; Dantas De Medeiros et al., 2018). The gene discussed is ADIPOQ; the disease is diabetes mellitus.