IL6 and Miyoshi myopathy: Importantly, the adhesion of MM cells to BMSCs and/or the extracellular matrix triggers the NF-κB-dependent transcription and secretion of cytokines such as IL-6, tumor necrosis factor-α, and osteopontin in BMSCs, which further stimulates development of drug resistance or so-called cell adhesion-mediated drug resistance (CAM-DR) [24,25,26].