In addition, Zhang et al. reported that the Hedgehog inhibitor LDE225 (sonidegib) inhibits MM cell proliferation by blocking Hedgehog signaling and modulates stromal cells within the BMM by decreasing the expression of VCAM-1 and other adhesion molecules, suggesting that Hedgehog inhibition is a promising option for the treatment of MM [46,47]. This evidence concerns the gene VCAM1 and Miyoshi myopathy.