BRAF and neoplasm: Several factors, including KRAS/BRAF mutation, the size of the largest tumor, the number of hepatic nodules, elevated serum tumor markers (CEA and CA 19-9), the interval between the primary tumor and the diagnosis of metastasis, the location, and the positive lymph node of the primary tumor have been found to be associated with oncological outcome after hepatectomy [12,13,14,15,16].