However, in prostate cancer cells, overexpression of TSP-2 was found to promote the expression of matrix metalloproteinase-2 (MMP-2) through the mitogen-activated protein kinase (MAPK) pathway, which in turn promoted tumor cell migration and invasion, and CD36 mediated TSP-2-induced MMP-2 activation and cell migration [85]. This evidence concerns the gene MMP2 and Familial prostate cancer.