THBS2 and neoplasm: On the one hand, in a mouse model, chronic diet-induced obesity was shown to promote vascular remodeling in breast cancer through the LPA/PKD-1-CD36 signaling axis, by significantly reducing CD36 expression, exhibiting its role in inhibiting angiogenesis [79]; on the other hand, CD36 can bind to the N TSP2-Fc fragment to induce caspase-3 production and reduce mitochondrial membrane potential in human dermal microvascular endothelial cells (HDMEC), activating the apoptotic pathway in HDMEC cells, thus acting as an inhibitor of tumor angiogenesis [80].