The results suggested that, the high expression of C1orf74, HK2, SLC22A3, SNX10 and URB2 and Neutrophils, as well as the low expression of RASSF5 and CD8+ T cells was related to the poor prognosis of CC patients, which might serve as the key prognostic biomarkers of tumor. This evidence concerns the gene HK2 and neoplasm.