FBXW7 and neoplasm: WD-repeat proteins are already known to be involved in tumorigenesis (Receptor for Activated C Kinase 1 (RACK1), cilia and flagella associated protein 52 (WDRPUH), Endonuclein (PWP1) and serine/threonine kinase receptor-associated protein (STRAP)) and also act as tumor suppressants (F-box and WD repeat domain containing 7 (FBW7) and serina/treonina quinase 11 (STK11)) [29,30,31,32,33,34].