The first time WRAP53 was described in cancer was after an analysis of the common genetic variation of TP53 and its flanking genes, and these data showed that the single nucleotide polymorphisms (SNPs) rs2287499 and rs2287498 were significantly linked to increased development of ER-negative breast cancer [117], and the same rs2287498 SNPs have also been linked to aggressive ovarian cancer [113,115]. This evidence concerns the gene TP53 and cancer.