The current study intended to evaluate the efficacy of a set of pyrazole derivatives synthesized in-house [7,8,9,10,11,12,13,14,15,16,17,18] (63 structures that are displayed in Supplementary Information) against six important cancer targets: CRMP2, C-RAF, CYP17, c-KIT, VEGFR, and HDAC9. Here, KDR is linked to cancer.