Thus, the involvement of SPRY4, ERRFI1, and MICALL1 in the regulation of EGFR/FGFR signaling feedback emphasizes the important role of hsa-miR: -130b-5p, -25-5p, -335-3p, and -34a-5p not only in the formation of NS, but also in the regulation of malignant growth and invasion of GBM through a negative feedback loop. This evidence concerns the gene EGFR and glioblastoma.