In both patient-derived BR3 and immortalized U87 MG GBM cells processes of NS formation proceeded with an increase in mRNA levels related to groups of “Epithelial Mesenchymal Transition” and “KRAS Signaling Up”, “TNF-alpha Signaling via NF-kB”, “Hypoxia”, “Apoptosis”, “Angiogenesis” (Table 2, “Upregulated”). Here, TNF is linked to glioblastoma.