Moreover, the analyzed association of the rs4848 and rs5746136 variants of the SOD2 gene in Mexican BC patients in our study, demonstrated that the dominant model of the CTTT genotype of the rs4880 variant was a risk factor for BC susceptibility stratified by different clinical pathology parameters, such as menopause, obesity (BMI 30–40), the presence of DM2-SAH, and a non-chemotherapy response. Here, SOD2 is linked to obesity due to melanocortin 4 receptor deficiency.