The BC patients who had the dominant model CTTT genotypes of the rs4880 SOD2 variant and displayed obesity (OR 3.7, 95% CI 1.07–12.9, p = 0.039), presence of DM2-SAH (OR 1.6, 95% CI 1.05–2.52, p = 0.028), and a non-chemotherapy response (OR 1.6, 95% CI 1.97–1.27, p = 0.002) showed a risk of developing BC. Here, SOD2 is linked to obesity disorder.