One of the TRPC6 agonists, N-(2-chlorophenyl)-2-(4-phenylpiperazine-1-yl) acetamide (51164), restores nSOCE, maintains mushroom spine percentage, and recovers synaptic plasticity in amyloidogenic mouse models of AD under conditions of amyloid toxicity [13]. The gene discussed is TRPC6; the disease is Alzheimer disease.