In a similar model, in which hyperuricemia was established in mice by combined administration of PO and hypoxanthine, Sonneratia apetala (mangrove Apple) seed oil showed to downregulate XOD activity and to increase protein expressions of GLUT9, URAT1, and OAT1, thus showing the dual inhibitory activity described above [56]. The gene discussed is SLC22A12; the disease is hyperuricemia.