Previous research found that the tumor-associated MSCs produced chemokines Gro-α/CXCL1, Gro-β/CXCL2, and IL8, which bound to the CXCR1/2 receptor on the surface of tumor cells and led to the formation of chemoresistance and induced the polarization of macrophages [44]. This evidence concerns the gene CXCL2 and neoplasm.