Our results indicated the changes in the mRNA levels of the BCL2, BCL2L1, BAX, CASP3, CAV1, and RAC1 genes as well as levels of the BCL2, BAX, CASP3, and CAV1 proteins associated with apoptosis and the malignant transformation of cells in the co-cultures of tumor, immune, and stromal cells in the presence of CDDP. This evidence concerns the gene RAC1 and neoplasm.