S100A9 caused pancreatic injury and inflammation by interacting directly with VNN1 and boosting the enormous production of reactive oxygen species (ROS), which activated NLRP3 inflammasome [137], as demonstrated by Xiang et al. In ALI, S100A8/A9 promoted neutrophil activation, damaged alveolar epithelial cells, and increased excessive inflammatory and immune responses in the airways and lung tissue. The gene discussed is IGKV1D-22; the disease is acute respiratory distress syndrome.