ICAM1, PSME2, FAM129A, SQSTM1, ANXA1, FCER1G, S100A6, CD44, GDA, IGHA2, and so on were among the most upregulated proteins, and COX6B1, SLC25A12, ACSL6, ADAM22, GJB6, LGI2, PVALB, EML2, SLC6A11, PDE10A, and so on were among the most downregulated proteins in PSP compared to PD. Here, S100A6 is linked to Parkinson disease.