ICAM1, PSME2, FAM129A, SQSTM1, ANXA1, FCER1G, S100A6, CD44, GDA, IGHA2, and so on were among the most upregulated proteins, and COX6B1, SLC25A12, ACSL6, ADAM22, GJB6, LGI2, PVALB, EML2, SLC6A11, PDE10A, and so on were among the most downregulated proteins in PSP compared to PD. The gene discussed is ANXA1; the disease is Parkinson disease.