ICAM1, PSME2, FAM129A, SQSTM1, ANXA1, FCER1G, S100A6, CD44, GDA, IGHA2, and so on were among the most upregulated proteins, and COX6B1, SLC25A12, ACSL6, ADAM22, GJB6, LGI2, PVALB, EML2, SLC6A11, PDE10A, and so on were among the most downregulated proteins in PSP compared to PD. This evidence concerns the gene CD44 and supranuclear palsy, progressive, 1.