P2RX4 and autosomal recessive polycystic kidney disease: To test this hypothesis, we assessed the chronic effects of ivermectin (P2X4R allosteric modulator) and 5‐BDBD (P2X4R antagonist) on the development of ARPKD in PCK/CrljCrl‐Pkhd1pck/CRL (PCK) rats.