This cluster, termed as activated MBC cluster 2 (actBC2), was enriched in several genes representing an activation phenotype comprising ITGAX (CD11c) and FAS (CD95) that has been previously associated with activated MBCs in COVID‐1923, 24 and influenza,25 along with age‐associated B cells24 (Supplementary table 1). The gene discussed is ITGAX; the disease is influenza.