In support of its role in myoCAF differentiation, ATM activation has additionally been reported to contribute to various fibrotic conditions, including systemic sclerosis (50), renal (51), and hepatocellular fibrosis (52), all myofibroblast-dependent processes, suggesting, overall, that the association of ATM signaling and myofibroblast/myoCAF phenotypes holds true across different tissues and disease pathogenesis. Here, ATM is linked to systemic sclerosis.