In PD, a study by Asikainen et al and colleagues investigated dysregulation ofmiRNAs in three C. elegans models bearing the human α-synucleinA53T mutation, or mutations within the vesicular catecholamine transporter(cat-1) or parkin (pdr-1) ortholog,reporting differential expression of several miRNAs in these models, includingmiR-64 and miR-65 families (Table 6).121 Another studyinvestigated miRNAs in C. elegans overexpressing human mutantα-synuclein and reported the dysregulation of 3 miRNAs when comparing mutants(HASNA53T OX) to controls expressing wildtype human α-synuclein(HASNWT OX).122. The gene discussed is SNCA; the disease is Parkinson disease.