Various studies have performed microarray analyses in the brain of a range ofmouse models of AD (Table6), including Tg2576,104,105 APP23,106APP/PS1,107, , -110 5xFAD,111,1123xTg-AD,113 SAMP8,45,114, -116 senescence-acceleratedmouse prone 10 (SAMP10),116 and PSEN dKO117 mice.Some of these studies focused on specific miRNAs, whilst others performeddetailed investigations of the cellular and molecular pathways affected andtargeted by these miRNAs. This evidence concerns the gene PSEN1 and Alzheimer disease.