SNCA and Parkinson disease: In a mouse model of PD induced by rotenone (a pesticide and complex I inhibitorthat reproduces features of PD, such as dopaminergic degeneration andα-synuclein inclusions), Tao et al102 showed reducedSirt1 levels in the substantia nigra, a region particularlyaffected in the PD brain due to the loss of dopaminergic neurons.