miRNA-sequencing (miRNA-seq) is a powerful method for miRNA profiling, which isreplacing the use of microarrays, particularly since it provides an unbiasedinvestigation of all miRNAs.123 Three studies to datehave conducted miRNA-seq to interrogate miRNAs in the APP/PS1 mouse model of AD(Table7).124, -126Specifically, Luo et al126 used 2 sibling pairs(transgenic mice and wildtype littermate controls) to identify AD-associatedmiRNA dysregulation. This evidence concerns the gene PSEN1 and Alzheimer disease.