Of the gender associated and SLE associated genes, CCR5 and ESR1 (increased in cisgender women), and PDGFB and MC1R (increased in cisgender men) are already established drug targets for HIV (CCR5); breast cancer, infertility, and obesity (ESR1); macular degeneration (PDGFB); and erythropoietic protoporphyria and kidney injury (MC1R; appendix 1 p 11). The gene discussed is MC1R; the disease is obesity due to melanocortin 4 receptor deficiency.