Based on its response to oxidative stress, the activation of TRPM2 channel mediates several neurodegenerative diseases, including Alzheimer’s disease (Aminzadeh et al., 2018), Parkinson’s disease (Ferreira et al., 2022), multiple sclerosis (Shao et al., 2021), and stroke (Zong et al., 2022). This evidence concerns the gene TRPM2 and neurodegenerative disease.