Together, these results suggest that even in the absence of Th2 immune response, Il-4rα-/-/Il-5-/- mice maintain the ability to replenish the alveolar niche with monocyte-derived cells upon infection and suggest that alveolar macrophages from Il-4rα-/-/Il-5-/- mice could mature faster than their WT counterpart. This evidence concerns the gene IL5 and infection.