Subsequently, we included the 63 IRGs in the LASSO Cox regression analysis, and the resulting five IRGs were finally included in the prediction model, including SPP1, BIRC5, STC2, GLP1R, and RAET1E. High expression of the five IRGs in the model resulted in a worse HCC prognosis. The gene discussed is GLP1R; the disease is hepatocellular carcinoma.