Moreover, consistently with previous observations in patients depicting CLR perturbations on pDCs mostly in blood circulation, pDCs were mostly impacted by tumor-derived supernatants, as we observed lower levels of DCIR+ and FcεRIα+ pDCs after 20h of culture with tumor supernatants (Figure 4E; Supplementary Figure 7E). The gene discussed is DCLK3; the disease is neoplasm.