MAPT and Alzheimer disease: The clinical diagnosis of AD presents with neuropathological changes, such as extracellular amyloid plaques composed of the amyloid β (Aβ) peptide, intraneuronal neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein, the binding of Apolipoprotein E to Aβ, the activation of immune mediators (including reactive astrogliosis and microgliosis), and reductions in synaptic density (3, 4).