In MPTP- or 6-OHDA-induced PD mice, icariin alleviates dopaminergic neuronal damage, decreases the secretion of pro-inflammation cytokines and inhibits the protein expression of Iba-1 and GFAP in brain through suppressing NLRP3 inflammasome activation and promoting Nrf2, Keap1, HO-1 and NQO1 protein production (59, 60). The gene discussed is AIF1; the disease is Parkinson disease.