Moreover, in PD, depression or ischemic stroke models, the other flavonoids compounds such as cyanidin-3-O-glucocide, agathisflavone and ginkgetin also exert anti-neuroinflammatory effects via PI3k/Akt, TLR4/NF-κB and MAPK pathways, which are shown in Table 2. Here, AKT1 is linked to major depressive disorder.