TRAF6 and intracerebral hemorrhage: In other studies, luteolin is reported to decrease the release of pro-inflammatory mediators (27, 28), decrease TRAF6, TLR4, and p-p65 expression as well as TRAF6 ubiquitination in the brain of intracerebral hemorrhage (ICH)-induced rats (27), suppress NLRP3 proteins expression and increase the activity of Nrf2 in the brain of subarachnoid hemorrhage-induced rats (28).