And in LPS-induced mice and Aβ1-42-induced AD mice, hesperetin is found to improve behavioral disorders, suppress astrocyte and microglia activation, and decrease iNOS and COX-2 production in the cortical and hippocampus of mice via inhibiting the protein expression of TLR4 and p-p65 (104–106). The gene discussed is TLR4; the disease is Alzheimer disease.