Besides, calycosin mitigates the behavioral dysfunctions, protects TH neurons and down-regulates the levels of pro-inflammatory mediators in the brain from MPTP‐induced PD mice via suppressing TLR2, TLR4, and nuclear NF-κB expression, as well as inhibiting p38, JNK and ERK phosphorylation (129). This evidence concerns the gene TLR4 and Parkinson disease.