In other studies, baicalein is reported to reduce IFN-γ, IL-5, and IL-12 secretion, as well as repress GFAP and Iba-1 expression in substantia nigra (SN) and midbrain from MPTP or rotenone-induced PD mice via downregulating cleaved-Caspase-1, cleaved-GSDMD, and NLRP3, as well as promoting PSD95, SYP, BDNF, p-TrkB, CREB, p-PI3k, p-Akt, and p-CaMK II expression (41, 42). This evidence concerns the gene CREB1 and Parkinson disease.