An imbalance in the ACE/ACE2 ratio was implicated in various pathological conditions including Alzheimer’s disease, pulmonary hypertension, cardiovascular, and renal pathology (Bernardi et al., 2012; Kehoe et al., 2016; Lavrentyev & Malik, 2009; Yuan et al., 2015). This evidence concerns the gene ACE and early-onset autosomal dominant Alzheimer disease.