GCLM and neoplasm: Here, we found that the ferroptosis regulators are frequently aberrant expressed in BCa, then we determined two heterogeneous clusters for BCa based on the expression levels of ferroptosis regulators, and found distinct prognosis and TIME between the two clusters, among these ferroptosis regulators, we further identified the GCLM as the key immune-related regulator, and knockdown its expression in BCa cells could significantly inhibit tumor progression.