Here, we systematically analyzed the relative expression, prognostic values and cluster of ferroptosis regulator genes in BCa, we constructed two heterogenous BCa clusters and discovered different clinical characteristics and prognosis between two clusters, Distinct tumor immune microenvironment (TIME), PD-L1 expression and sensitivity to immunotherapy were also found between this two clusters, which will help to stratify different risk BCa patients and guide further treatment. Here, CD274 is linked to neoplasm.