Of interest, MALAT1 causes poor disease-free survival and overall survival in patients who have received 5-FU-based adjuvant therapy; moreover, this lncRNA induces the resistance of GC cells to cisplatin, 5-FU and vincristine by triggering autophagy through sequestration of miR-23b-3p and then elevating ATG12 levels (108). The gene discussed is ATG12; the disease is gastric cancer.