Some chemokines, such as CCL5 (RANTES), CXCL10 and CCL2 induced by TNFα, also have been reported to locally recruit both CAR T cells and endogenous T cells when combined with adenoviral OV and mesothelin-redirected CAR T cells in pancreatic ductal adenocarcinoma model (26). Here, TNF is linked to pancreatic ductal adenocarcinoma.