CD19 and neoplasm: T7011 was designed to selectively infect a large spectrum of solid tumors and drive tumor-specific expression of CAR-targetable tumor antigens by inserting truncated CD19 and BCMA as well as chemokine CCL5 gene into the loci between UL37 and UL38 with the aid of Bacterial Artificial Chromosome (BAC) technology (Supplementary Figure 1).