The sites of predilection for Krox20-Cre; Pik3caH1047R/+ vascular lesions were within the panniculus carnosus and epaxial skeletal muscle groups, compatible with intramuscular hemangioma, a tumor rather than a vascular malformation (Tan et al., 2007; Kurek et al., 2012). The gene discussed is EGR2; the disease is neoplasm.