PIK3CA and vascular malformation: Somatic mutation of codon H1047 is frequently but not exclusively implicated in asymmetric, multi-systemic PIK3CA-related overgrowth disorders such as CLOVES (OMIM 612918; congenital lipomatous overgrowth, vascular malformations, epidermal nevi and skeletal abnormalities) and endophenotypic segmental overgrowth syndromes affecting muscle and fat, or fibroadipose hyperplasia.