TNF and myocardial ischemia: It has been shown that puerarin reduced the mRNA and protein levels of Tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and IL-1β in a mouse model of myocardial ischemia/reperfusion (MI/R) injury, inhibited NLRP3 inflammasome and protected the heart (Wang et al., 2020).