In CCL4-induced liver fibrosis, artemether significantly downregulated many markers of HSC activation, including α-SMA, Col1a1, and fibronectin, and inhibited profibrotic receptors such as TGF-βR1, PDGF-βR and epidermal growth factor receptor (Wang et al., 2019). This evidence concerns the gene CCL4 and Hepatic fibrosis.