IL-10 gene therapy can alleviate liver fibrosis in rats upon CCL4 injection by restoring HSC senescence in the fibrotic liver, however, the effect is abrogated in p53 knockout rats, indicating p53 is required for the anti-fibrosis effect of IL-10 (Guo et al., 2021). The gene discussed is TP53; the disease is Hepatic fibrosis.