BRD7 directly binds to the N-terminal transactivation domain to promote mitochondrial translocation of p53, which in turn forms a complex with SLC25A28 to enhance the activity of SLC25A28, resulting in abnormal accumulation of redox-active iron and electron transfer chain hyperfunction, enhanced ferroptosis in HSCs and improved the degree of liver fibrosis in mice (Zhang et al., 2020). The gene discussed is TP53; the disease is Hepatic fibrosis.