HIF1A and atherosclerosis: Figure 5B shows that many signaling pathways are closely related to CRC, such as the AGE-RAGE in diabetic complications, TNF, IL-17, toll-like receptors, C-type lectin receptors, fluid shear stress, atherosclerosis, human cytomegalovirus infection, pathogenic Escherichia coli infection, endocrine resistance, apoptosis, HIF-1 signaling pathway, colorectal cancer signaling pathway, small-cell lung cancer signaling pathway, osteoclast differentiation, and bladder cancer signaling pathway. The correlation between the core network and the top 15 vital signaling pathways is shown in Figure 4E.