Figure 5B shows that many signaling pathways are closely related to CRC, such as the AGE-RAGE in diabetic complications, TNF, IL-17, toll-like receptors, C-type lectin receptors, fluid shear stress, atherosclerosis, human cytomegalovirus infection, pathogenic Escherichia coli infection, endocrine resistance, apoptosis, HIF-1 signaling pathway, colorectal cancer signaling pathway, small-cell lung cancer signaling pathway, osteoclast differentiation, and bladder cancer signaling pathway. The correlation between the core network and the top 15 vital signaling pathways is shown in Figure 4E. This evidence concerns the gene HIF1A and escherichia coli infection.