Inflammation is highly correlated with oxidative stress, and their biochemical indexes were highly positively correlated with the metabolites enriched in the model group, such as PKG1, DG (15:0/18:4(6Z,9Z,12Z,15Z)/0:0), stercobilin, 17-phenyl-18,19,20-trinor-prostaglandin E2, etc., and many of them were also related to insulin resistance, which had a positive relation with g_Ruminococcus_gauvreauii_group, g_Ruminococcus_torques_group, g_Blautia, g_Allobaculum. This evidence concerns the gene PRKG1 and Insulin resistance.