TNF and nervous system disorder: However, in some conditions, studies have found that cytokines such as TNFα, IL-1β, and IL-6 can also improve the outcome of diseases such as ADs and that neutralizing or knocking out these cytokines can eventually attenuate the progression of neurological diseases or injuries (Goshen et al., 2007; Yasutaka et al., 2015; Han et al., 2016; Patin et al., 2016).