Mario et al. (2010) have found that mice undergoing surgery of the tibia under general anesthesia have an extreme increasement of IL-1β in hippocampal and then inducing memory and cognitive impairment (Mario et al., 2010). Our research indicated that burn disrupted BBB both increasing the paracellular pathway and transcytosis through increasing the peripheral level of IL-1β and IL-6 (Yang J. et al., 2020). This evidence concerns the gene IL6 and Cognitive impairment.