NOS2 and nervous system disorder: Under this condition, the abnormal increasing pro-inflammatory cytokines such as TNFα (Chen et al., 2019), interleukin-1beta (IL-1β) (Hauptmann et al., 2020), interleukin-6 (IL-6) (Yang et al., 2017; Yang J. et al., 2020), interferon-γ (INF-γ) (Bonney et al., 2019), and inducible nitric oxide synthase (iNOS) (Smith et al., 2018) can compromise BBB permeability and induce or deteriorate neurological disorders which make the regulation of inflammation more difficult (Ren et al., 2020).