In addition, it was observed that patients with Alzheimer's type dementia had lower adherence to treatment compared to patients with other types of dementia, e.g., vascular, frontotemporal, etc. This low adherence may be associated with the prescription of higher number of specific drugs (e.g., acetylcholinesterase inhibitors, NMDA receptor antagonists) and polymedication with the subsequent potential greater incidence of adverse effects (40). The gene discussed is ACHE; the disease is dementia.