-5/9 males had normal gonadal function (normal LH, FSH, testosterone)- 3/9 males had hypogonadism with normal testosterone-1/9 male required testosterone- 2/4 females developed POF requiring therapy-2/4 females had normal cycles and hormone levels- 1 pregnancy (unspecified if spontaneous). Here, PLOD1 is linked to hypogonadism.