Similar results were observed in a study in which immunohistochemical (IHC) staining of renal biopsy tissue of DN patients revealed that OPG was mainly expressed in renal tubules instead of the glomerulus, and the expression of OPG was higher in patients with albuminuria than in those with microalbuminuria (60). The gene discussed is TNFRSF11B; the disease is liver dysplastic nodule.