During the course of follow-up, 10 (4 boys) pubertal subjects with NCCAH received GnRHa therapy: 6 (2 boys) were treated with GnRHa alone for the indication of precocious puberty and 4 were treated with a combination of GnRHa and GH due to predicted short stature in adulthood. This evidence concerns the gene GH1 and precocious puberty.