The tumor size (2.56 [1.53-4.56]), lymph node (4.06 [1.28-13.96]), serum NSE (3.98 [1.18-18.30]), HGB (0.96[0.90-0.99]), age (1.10 [1.05-1.17]) and sex (3.51 [1.10-12.10]) were independently associated with G3 grade (Table 3). Here, ENO2 is linked to neoplasm.