ZhimingDong et al. have shown that (Dong et al., 2019) the down-regulation of tumor suppressor genes SEMA3B and lncRNA SEMA3B-AS1 mediated by hypermethylation of promoter is related to the progression and prognosis of esophageal squamous cell carcinoma. The gene discussed is SEMA3B; the disease is esophageal squamous cell carcinoma.