BRCA1 and ovarian cancer: While pathogenic variants in other genes including PALB2, RAD51C, RAD51D, and BRIP1 also cause hereditary breast and ovarian cancer, we focus this review on BRCA1/2 because of the higher frequency of pathogenic variants in the population in these genes, and established clinical management guidelines (Manickam et al., 2018; National Comprehensive Cancer Network (NCCN), 2021a).