BRCA1 and breast cancer: A systematic review of the harms of breast cancer screening among average-risk females found that harms included overdiagnosis (at rates of 11%–22% from randomized controlled trials [RCTs]) and false positive results which were associated with elevated anxiety, distress, and breast-cancer specific worry; however, the review only included females at average-risk and excluded those with pathogenic BRCA1/2 variants (Nelson et al., 2016).