Zhang et al. (2019) detected HCC specific immune cells for five HCC patients using scRNA-seq and discovered that CD45 immune cells, LAMP3(+) dendritic cells, and tumor-associated macrophages were specific infiltrating immune cells in HCC and were associated with patients’ poor prognosis. Ho et al. (2019) grouped HCC stem cells for two subgroups through scRNA-seq according to the expression of EPCAM; they also identified a CD24/CD44-enriched cell subpopulation within the EPCAM(+) cells which might indicate a novel stemness-related cell subclone of HCC. Here, CD44 is linked to hepatocellular carcinoma.