METTL1/WDR4 is the core regulator of m7G modification and exerts a powerful oncogenic role in acute myeloid leukemia (AML) (Orellana et al., 2021), bladder cancer (BC) (Ying et al., 2021), esophageal squamous cell carcinoma (ESCC) (Han et al., 2022), glioma (Li et al., 2021a), hepatocellular carcinoma (HCC) (Tian et al., 2019; Chen et al., 2021; Xia et al., 2021), head and neck squamous cell carcinoma (HNSCC) (Chen et al., 2022), etc., promoting the malignant phenotype and progression of tumors. This evidence concerns the gene WDR4 and hepatocellular carcinoma.