However, a recent study investigated the functions of m7G regulators WBSCR22 and TRMT112 in pancreatic cancer (PC) and found that WBSCR22 was downregulated in PC samples when compared with adjacent normal pancreatic tissue and WBSCR22 cooperates with TRMT112 to exert a tumor suppressor effect in PC, associated with longer survival of patients (Khan et al., 2022). The gene discussed is TRMT112; the disease is pachyonychia congenita.