Using the Louvain clustering algorithm and a KNN graph, melanoma tissue was divided into the major cell types as follows: B cells, CD4-positive T cells, CD8-positive exhausted T cells, endothelial cells, fibroblasts, SKCM cells, monocytes, follicular helper T cells, Th1 helper cells, and proliferating T cells (8A, G). This evidence concerns the gene CD4 and melanoma.