RUNX3 and central nervous system cancer: Similar to KEGG and GO enrichment analysis, immune biological process genesets (RUNX3 regulates immune response and cell migration, leukocyte transendothelial migration) and matrix-related pathways (ECM receptor interaction, glycosaminoglycan degradation, glycosaminoglycan biosynthesis keratan sulfate) were also activated in the glioma with high-risk score.