Polymorphisms in the CDKAL1 gene are reported to be associated with type 2 diabetes mellitus in several human populations (Hu et al., 2009; Han et al., 2010; Naser et al., 2021; Amin et al., 2022; Ghosh et al., 2022), and the CDKAL1 gene is involved in the metabolism of insulin that affects glucose mediated mechanisms, crucial for feed-efficiency and other growth and adaptation traits (Santos et al., 2020). The gene discussed is INS; the disease is type 2 diabetes mellitus.