In addition, Pou4f1 in the competition network inhibited neuronal apoptosis, Slc18a2 negatively regulated neurotransmitter transport, Shox2 and Irx5 were associated with neurodevelopment, and the transmembrane protein TMEM also played an important role in human immune-related diseases as well as tumor development (57, 58). Here, IRX5 is linked to neoplasm.